David Burke is a small time drug peddler. He accidentally loses some of his stash, a part of which belongs to the drug lord, Brad. In order to pay back, David agrees to smuggle marijuana from Mexico. As David does not have a family of his own, he manages to get some people to help in his ordeal by posing as his family as otherwise it would be difficult to convince the customs officials. So David, together with his ragtag group of friends make up a family called “the Millers”. On their way back from Mexico ,the Millers encounter many hilarious situations but ,manage to smuggle back the marijuana.